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KMID : 0357220010130010237
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Journal of Korean Society Physical Therapy
2001 Volume.13 No. 1 p.237 ~ p.243
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Review of Sarcoplasmic Reticulum Ca` Releasing Mechanisms in Skeletal Muscle Contraction
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Abstract
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Skeletal muscle cells are activated by a-motorneurons which release acetylcholine at the neuromuscular junction. This results in a local depolarization of surface membrane which triggers an action potential. The action potential propagates along the surface membrane and also into the T-tubule system. In the triads Ttubules are in close connection with the terminal cisternae of the sarcoplasmic reticulum(SR). The action potential activates T-tubule voltage sensors(DHP receptors), which activates SR Cal´ release channels(ryanodine receptors). Ca´-´ have a key role in skeletal muscle in that an increase of free myoplasmic Ca" concentration.
The process of coupling chemical and electrical signals at the cell surface to the intracellular release of Cal´ and ultimate contraction of muscle fibers is termed excitation-contraction coupling(ECC). Coupling of cell surface signals to intracellular Cal´ release proceeds by several mechanisms in skeletal muscle cells.
This review focus on sarcoplasmic reticulum(SR) Cal´ releasing mechanisms from sarcoplasmic reticulum in the skeletal muscle. The mechanisms include DCCR, CICR, and 11CR.
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KEYWORD
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